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Immunologic study of gonadotropins in serum was performed in order to determine the effect of oophorectomy in the premenopausal women upon the serum concentrations of gonadotropins and to compare the hormonal levels with those of spontaneous postmenopausal women. The concentrations of gonadotropins were measured by methods based upon the principles of radioimmunoassay. The results of the comparative study of the gonadotropin concentrations before and after oophorectomy in premenopausal women versus spontaneous postmenopausal women were summarized as follows: 1. The gonadotropin concentrations were increased abruptly in immediate postoperative stage to the levels of 51.7mIU/ml in FSH and 40.8mIU/ml in LH in 7th postoperative day comparing with the levels of 15.3mIU/ml and 21.7mIU/ml respectively prior to the operation. 2. In two weeks after the operation, FSH concentration reached to the level of 81.8mIU/ml and LH, of 73.4mIU/ml, which was considered as a peak through 10 years after oophorectomy. 3. In one year after the operation, FSH concentration showed 88.3mIU/ml and LH, 50.5mIU/ml, followed by the gradual decrease to 46.5mIU/ml of FSH and 45.1mIU/ml of LH in 10 years after oophorectomy. 4. In the spontaneous menopause, gonadotropin concentrations were gradually increased to the levels of 63.5mIU/ml of FSH and 68.5mIU/ml of LH at 3 years after the menopause, which were considered as a peak. And the levels of FSH and LH showed gradual decrease to 44.7mIU/ml and 47.2mIU/ml respectively in 10 years after the monopause. In conclusion, gonadotropin concentrations of premenopausal oophorectomized women were increased abruptly and the maximal concentrations were observed in 2 weeks after the operation whereas maximal concentrations in the spontaneous menopause, in 3 years. And their maximal values were significantly higher in oophorectomized women than in the spontaneous menopausal women, but those values after 10 years showed the same levels in both groups.
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